医薬品リファレンス
Prucalopride
Prucalopride is a medicine in the class gastrointestinal tract. It is used for constipation.
- 薬効分類: Gastrointestinal Tract
- 効能・効果: constipation
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Gastrointestinal Tract
- ATCコード
- A06AX05
- 一般的な剤形
- 錠剤
- 一般的な規格
- 2 mg, 1 mg
- 既知の相互作用
- 1 (中等度: 1)
- 商品名
- 16
- 国・市場
- 5
何に使われるか
作用のしくみ
Selective serotonin type 4 (5-HT4) receptor agonist; elicits GI prokinetic actions that stimulates colonic peristalsis (high-amplitude propagating contractions [HAPCs]), which increases bowel motility.
成人の通常用量（添付文書の要約）
Chronic Idiopathic Constipation: 2 mg orally once a day.
妊娠と授乳
- 妊娠
- Unknown Limited human data (case reports); no harm in rats or rabbits at 390 to 780 times the human dose. Miscarriages occurred in trials, link to the drug unclear. EU label: not recommended in pregnancy or without contraception. Prefer a better-studied laxative (bulk-forming, macrogol).
- 授乳
- Unknown Passes into milk: about 6% of the mother's weight-adjusted dose in a US label study; no data on infant effects. UK label: no infant effects expected, but decide whether to stop breastfeeding or the drug; US label: weigh benefits. LactMed: monitor the infant for diarrhoea.
報告されている副作用
- Headache
- Diarrhea
- Nausea
- Abdominal pain
禁忌
- Hypersensitivity
- Intestinal perforation or obstruction due to structural or functional disorder of gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract (eg, Crohn disease, ulcerative colitis, toxic megacolon/megarectum)
注意が必要な方
- Suicidal ideation and behavior In clinical trials, suicides, suicide attempts, and suicidal ideation reported.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (1)
- Mosapride + Prucalopride Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Prucaloprideの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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よくある質問
What is Prucalopride used for?
Prucalopride is a medicine in the class gastrointestinal tract. It is used for Constipation.
What side effects have been reported with Prucalopride?
Headache, Diarrhea, Nausea, Abdominal pain.
Can Prucalopride be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data (case reports); no harm in rats or rabbits at 390 to 780 times the human dose. Miscarriages occurred in trials, link to the drug unclear. EU label: not recommended in pregnancy or without contraception. Prefer a better-studied laxative (bulk-forming, macrogol). Breastfeeding: Unknown. Passes into milk: about 6% of the mother's weight-adjusted dose in a US label study; no data on infant effects. UK label: no infant effects expected, but decide whether to stop breastfeeding or the drug; US label: weigh benefits. LactMed: monitor the infant for diarrhoea.
What does Prucalopride interact with?
MediHelp lists 1 known interactions for Prucalopride. Moderate: 1. The most serious include Mosapride.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
