医薬品リファレンス
Sodium phenylbutyrate
Sodium phenylbutyrate is a medicine in the class miscellaneous.
- 薬効分類: Miscellaneous
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- ATCコード
- A16AX03
- 一般的な剤形
- 錠剤, 散剤
- 一般的な規格
- 483 mg/g
- 既知の相互作用
- 3 (重大: 1 · 中等度: 2)
- 商品名
- 4
- 国・市場
- 2
作用のしくみ
Prodrug metabolized to phenylacetate, which conjugates with glutamine to form phenylacetylglutamine; this is excreted by the kidneys, providing an alternate route for waste nitrogen excretion.
成人の通常用量（添付文書の要約）
Urea cycle disorders, patients weighing 20 kg or more: 9.9 - 13 g/m2/day of sodium phenylbutyrate orally in three to six divided doses with food; maximum 20 grams per day
妊娠と授乳
- 妊娠
- Unsafe No human data. In rats, prenatal exposure to its active metabolite phenylacetate damaged developing brain cells. Untreated urea cycle disorders are dangerous; specialist care is essential. EU label: contraindicated in pregnancy, with effective contraception; US label: use only if clearly needed.
- 授乳
- Unknown Not known if it passes into milk. EU label: contraindicated while breastfeeding (brain damage in rat pups given phenylacetate). LactMed: highly protein bound, unlikely in important amounts; not a reason to stop, but use with caution with a newborn and watch for sedation or vomiting.
報告されている副作用
- Amenorrhea or menstrual dysfunction
- Decreased appetite
- Body odor
- Bad taste or taste aversion
注意が必要な方
- Neurotoxicity from phenylacetate; consider dose reduction if symptoms are present.
- Hypokalemia: urinary potassium loss; monitor serum potassium.
- Sodium content may cause edema; discontinue if new or worsening edema occurs.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (3)
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アカウントを作成してPro+トライアルを始めると、Sodium phenylbutyrateの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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よくある質問
What is Sodium phenylbutyrate used for?
Sodium phenylbutyrate is a medicine in the class miscellaneous.
What side effects have been reported with Sodium phenylbutyrate?
Amenorrhea or menstrual dysfunction, Decreased appetite, Body odor, Bad taste or taste aversion.
Can Sodium phenylbutyrate be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data. In rats, prenatal exposure to its active metabolite phenylacetate damaged developing brain cells. Untreated urea cycle disorders are dangerous; specialist care is essential. EU label: contraindicated in pregnancy, with effective contraception; US label: use only if clearly needed. Breastfeeding: Unknown. Not known if it passes into milk. EU label: contraindicated while breastfeeding (brain damage in rat pups given phenylacetate). LactMed: highly protein bound, unlikely in important amounts; not a reason to stop, but use with caution with a newborn and watch for sedation or vomiting.
What does Sodium phenylbutyrate interact with?
MediHelp lists 3 known interactions for Sodium phenylbutyrate. Major: 1 · Moderate: 2. The most serious include Sodium valproate, Haloperidol, Probenecid.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
