相互作用
Sodium phenylbutyrate + Sodium valproate
重症度: 重大
Sodium phenylbutyrate and Sodium valproate: major interaction.
最終更新日
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概要
Valproate can cause hyperammonemia and may counteract the ammonia-lowering effect of phenylbutyrate in urea cycle disorders. This can precipitate hyperammonemic encephalopathy.
この相互作用をわかりやすく説明すると
Sodium phenylbutyrate and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sodium phenylbutyrate belongs to Miscellaneous; Sodium valproate belongs to Central Nervous System.
なぜ起こるのか
Valproate inhibits urea cycle function and depletes carnitine, which raises ammonia.
対処法
Avoid valproate in urea cycle disorders if possible and choose another anticonvulsant. If unavoidable, monitor plasma ammonia closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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アカウントを作成してPro+トライアルを始めると、Sodium phenylbutyrateとSodium valproateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sodium phenylbutyrateのその他の相互作用
Sodium valproateのその他の相互作用
よくある質問
Can I take Sodium phenylbutyrate with Sodium valproate?
MediHelp rates the interaction as major. Sodium phenylbutyrate and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valproate can cause hyperammonemia and may counteract the ammonia-lowering effect of phenylbutyrate in urea cycle disorders. This can precipitate hyperammonemic encephalopathy.
How serious is the interaction between Sodium phenylbutyrate and Sodium valproate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid valproate in urea cycle disorders if possible and choose another anticonvulsant. If unavoidable, monitor plasma ammonia closely.
What other medicines interact with Sodium phenylbutyrate?
MediHelp also lists interactions of Sodium phenylbutyrate with, for example, Haloperidol, Probenecid. The full list is on the Sodium phenylbutyrate page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
