医薬品リファレンス
Tipranavir
Tipranavir is a medicine in the class anti virals. It is used for hiv.
- 薬効分類: Anti Virals
- 効能・効果: hiv
最終更新日 出典: EMA SmPC
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Anti Virals
- ATCコード
- J05AE09
- 既知の相互作用
- 276 (併用禁忌: 26 · 重大: 96 · 中等度: 132 · 軽度: 22)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Tipranavir is a non-peptidic HIV-1 protease inhibitor that blocks maturation of viral particles and so inhibits viral replication.
成人の通常用量（添付文書の要約）
HIV-1 infection (highly pre-treated, adults and adolescents 12-18 years with BSA ≥ 1.3 m2 or weight ≥ 36 kg): 500 mg tipranavir with 200 mg ritonavir, oral, twice daily; ritonavir doses below 200 mg twice daily should not be used
妊娠と授乳
- 妊娠
- Unknown Limited data (no birth defects in 13 1st-trimester registry exposures); reproductive toxicity in animals. EU label: use only if benefit justifies the risk. It weakens estrogen pills; use another contraceptive. Better-studied HIV drugs are preferred in pregnancy.
- 授乳
- Unknown No human milk data; present in rat milk. EU label: women with HIV should not breastfeed (transmission). US guidance supports breastfeeding with sustained viral suppression after counselling; otherwise use formula or donor milk (LactMed).
報告されている副作用
- Rash
禁忌
- Hypersensitivity to the active substance or excipients
- Moderate or severe (Child-Pugh B or C) hepatic impairment
- Rifampicin combination with Aptivus/low dose ritonavir
注意が必要な方
- Must be given with low dose ritonavir; otherwise tipranavir levels may be insufficient
- Hepatotoxicity: clinical hepatitis and hepatic decompensation, including fatalities; monitor liver tests; discontinue if ASAT/ALAT rise above 10X ULN
- Should not be used in treatment-naive patients
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (276)
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
- Dronedarone + Tipranavir Contraindicated
- Eletriptan + Tipranavir Contraindicated
- Eplerenone + Tipranavir Contraindicated
- Ergotamine + Tipranavir Contraindicated
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Tipranavirの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
関連するクイックリード
よくある質問
What is Tipranavir used for?
Tipranavir is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Tipranavir?
Rash.
Can Tipranavir be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited data (no birth defects in 13 1st-trimester registry exposures); reproductive toxicity in animals. EU label: use only if benefit justifies the risk. It weakens estrogen pills; use another contraceptive. Better-studied HIV drugs are preferred in pregnancy. Breastfeeding: Unknown. No human milk data; present in rat milk. EU label: women with HIV should not breastfeed (transmission). US guidance supports breastfeeding with sustained viral suppression after counselling; otherwise use formula or donor milk (LactMed).
What does Tipranavir interact with?
MediHelp lists 276 known interactions for Tipranavir. Contraindicated: 26 · Major: 96 · Moderate: 132 · Minor: 22. The most serious include Alfuzosin, Amiodarone, Atorvastatin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
