相互作用
Avanafil + Tipranavir
重症度: 併用禁忌
Avanafil and Tipranavir: contraindicated interaction.
最終更新日
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概要
Tipranavir, which is given with ritonavir, strongly inhibits CYP3A4 and can markedly raise avanafil exposure. This may cause profound hypotension, syncope, visual disturbances and prolonged erection or priapism.
この相互作用をわかりやすく説明すると
Avanafil and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Tipranavir belongs to Anti Virals.
なぜ起こるのか
Ritonavir-boosted tipranavir inhibits CYP3A4-mediated first-pass and hepatic metabolism of avanafil, reducing its clearance.
対処法
Do not combine avanafil with ritonavir-boosted tipranavir. Choose a non-CYP3A4-dependent option for erectile dysfunction, or use a PDE5 inhibitor at a labeled reduced dose with specialist advice.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AvanafilとTipranavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Avanafilのその他の相互作用
Tipranavirのその他の相互作用
よくある質問
Can I take Avanafil with Tipranavir?
MediHelp rates the interaction as contraindicated. Avanafil and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir, which is given with ritonavir, strongly inhibits CYP3A4 and can markedly raise avanafil exposure. This may cause profound hypotension, syncope, visual disturbances and prolonged erection or priapism.
How serious is the interaction between Avanafil and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine avanafil with ritonavir-boosted tipranavir. Choose a non-CYP3A4-dependent option for erectile dysfunction, or use a PDE5 inhibitor at a labeled reduced dose with specialist advice.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
