医薬品リファレンス
Trihexyphenidyl
Trihexyphenidyl is a medicine in the class central nervous system. It is used for parkinson disease.
- 薬効分類: Central Nervous System
- 効能・効果: parkinson disease
最終更新日
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要点
- 薬効分類
- Central Nervous System
- 別名
- Benzhexol
- 一般的な規格
- 5 mg, 2 mg
- 既知の相互作用
- 89 (重大: 5 · 中等度: 77 · 軽度: 7)
- 商品名
- 3
- 国・市場
- 1
何に使われるか
作用のしくみ
Trihexyphenidyl inhibits the parasympathetic nervous system and has a relaxing effect on smooth muscles
成人の通常用量（添付文書の要約）
Parkinson Disease Initial: 1 mg PO first day, then increase by 2 mg q3-5days until reach 6-10 mg/days
妊娠と授乳
- 妊娠
- Unknown Limited human data and no animal studies; no clear pattern of birth defects. Near term, anticholinergics given with antipsychotics have caused newborn bowel problems (paralytic ileus). US label: only if clearly needed. Use the lowest dose and tell the delivery team.
- 授乳
- Unknown Limited data: up to 4 mg daily with haloperidol or risperidone caused no infant effects. LactMed: long-term use might reduce milk production or let-down (less likely with antipsychotics that raise prolactin); watch milk supply and infant weight gain.
報告されている副作用
- Rash
- Anticholinergic side effects
- Suppurative parotitis
- Hallucination
注意が必要な方
- Exacerbation of parkinsonism, neuroleptic malignant syndrome, and withdrawal symptoms results of therapy discontinuation or dose reduction; should be withdrawn gradually
- Use extreme caution and monitor closely patients with liver, cardiac, kidney disorders, prostatic hyperplasia (urinary stricture), or with hypertension
- Drug has atropine-like properties; use with caution in patients with glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts and in elderly males
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (89)
- Orphenadrin + Trihexyphenidyl Major
- Oxybutynin + Trihexyphenidyl Major
- Scopolamine + Trihexyphenidyl Major
- Solifenacin + Trihexyphenidyl Major
- Trihexyphenidyl + Trospium Major
- Abobotulinumtoxina + Trihexyphenidyl Moderate
- Aclidinium + Trihexyphenidyl Moderate
- Amantadine + Trihexyphenidyl Moderate
- Amitriptyline + Trihexyphenidyl Moderate
- Amoxapine + Trihexyphenidyl Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Trihexyphenidylの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Dosing in older adults
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Trihexyphenidyl used for?
Trihexyphenidyl is a medicine in the class central nervous system. It is used for Parkinson disease.
What side effects have been reported with Trihexyphenidyl?
Rash, Anticholinergic side effects, Suppurative parotitis, Hallucination.
Can Trihexyphenidyl be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data and no animal studies; no clear pattern of birth defects. Near term, anticholinergics given with antipsychotics have caused newborn bowel problems (paralytic ileus). US label: only if clearly needed. Use the lowest dose and tell the delivery team. Breastfeeding: Unknown. Limited data: up to 4 mg daily with haloperidol or risperidone caused no infant effects. LactMed: long-term use might reduce milk production or let-down (less likely with antipsychotics that raise prolactin); watch milk supply and infant weight gain.
What does Trihexyphenidyl interact with?
MediHelp lists 89 known interactions for Trihexyphenidyl. Major: 5 · Moderate: 77 · Minor: 7. The most serious include Orphenadrin, Oxybutynin, Scopolamine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
