相互作用
Solifenacin + Trihexyphenidyl
重症度: 重大
Solifenacin and Trihexyphenidyl: major interaction.
最終更新日
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概要
Both drugs are antimuscarinic, so combined use can produce marked dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older adults are especially vulnerable to cognitive impairment and delirium.
この相互作用をわかりやすく説明すると
Solifenacin and Trihexyphenidyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Solifenacin belongs to Genitourinary; Trihexyphenidyl belongs to Central Nervous System.
なぜ起こるのか
Additive antagonism of muscarinic receptors.
対処法
Avoid the combination where possible, particularly in older adults. If necessary, use the lowest effective doses and monitor for urinary retention, constipation and cognitive changes.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、SolifenacinとTrihexyphenidylの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Solifenacinのその他の相互作用
Trihexyphenidylのその他の相互作用
よくある質問
Can I take Solifenacin with Trihexyphenidyl?
MediHelp rates the interaction as major. Solifenacin and Trihexyphenidyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are antimuscarinic, so combined use can produce marked dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older adults are especially vulnerable to cognitive impairment and delirium.
How serious is the interaction between Solifenacin and Trihexyphenidyl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in older adults. If necessary, use the lowest effective doses and monitor for urinary retention, constipation and cognitive changes.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
