医薬品リファレンス
Vandetanib
Vandetanib is a medicine in the class oncology. It is used for thyroid cancer.
- 薬効分類: Oncology
- 効能・効果: thyroid cancer
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- 一般的な剤形
- 錠剤
- 既知の相互作用
- 137 (併用禁忌: 42 · 重大: 71 · 中等度: 20 · 軽度: 4)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Vandetanib inhibits the tyrosine kinase activity of the EGFR and VEGFR families, RET, BRK, TIE2, and members of the EPH receptor and Src kinase families.
成人の通常用量（添付文書の要約）
Medullary thyroid cancer (symptomatic or progressive, unresectable locally advanced or metastatic): 300 mg orally once daily until disease progression or unacceptable toxicity
妊娠と授乳
- 妊娠
- Unsafe Can cause fetal harm; no human data. Embryotoxic, fetotoxic and caused fetal malformations in rats. Verify pregnancy status before starting and use effective contraception.
- 授乳
- Unsafe No human milk data; present in rat milk. Advise not to breastfeed during treatment and for 4 months after the last dose.
報告されている副作用
- Diarrhea/colitis
- Rash
- Acneiform dermatitis
- Hypertension
- Nausea
- Headache
警告（枠囲み警告）
- Can prolong the QT interval; torsades de pointes and sudden death have occurred. Do not use in patients with hypocalcemia, hypokalemia, hypomagnesemia, or long QT syndrome. Correct hypocalcemia, hypokalemia and/or hypomagnesemia before administration, monitor electrolytes periodically, and avoid drugs known to prolong the QT interval.
禁忌
- Congenital long QT syndrome
注意が必要な方
- QT prolongation: do not start if QTcF >450 ms; obtain ECG and potassium, calcium, magnesium and TSH at baseline, 2 to 4 weeks, 8 to 12 weeks, then every 3 months.
- Severe, sometimes fatal skin reactions including TEN and Stevens-Johnson syndrome; permanently discontinue for severe reactions. Photosensitivity can occur up to 4 months after discontinuation.
- Interstitial lung disease/pneumonitis, including fatalities; discontinue if confirmed.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (137)
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
- Chlorpromazine + Vandetanib Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Citalopram + Vandetanib Contraindicated
- Clomipramine + Vandetanib Contraindicated
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Vandetanibの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Vandetanib used for?
Vandetanib is a medicine in the class oncology. It is used for Thyroid cancer.
What side effects have been reported with Vandetanib?
Diarrhea/colitis, Rash, Acneiform dermatitis, Hypertension, Nausea, Headache. Serious warning: Can prolong the QT interval; torsades de pointes and sudden death have occurred.
Can Vandetanib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm; no human data. Embryotoxic, fetotoxic and caused fetal malformations in rats. Verify pregnancy status before starting and use effective contraception. Breastfeeding: Unsafe. No human milk data; present in rat milk. Advise not to breastfeed during treatment and for 4 months after the last dose.
What does Vandetanib interact with?
MediHelp lists 137 known interactions for Vandetanib. Contraindicated: 42 · Major: 71 · Moderate: 20 · Minor: 4. The most serious include Amiodarone, Amisulpride, Amitriptyline.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
