医薬品リファレンス
Venetoclax
Venetoclax is a medicine in the class miscellaneous. It is used for chronic lymphocytic leukemia.
- 薬効分類: Miscellaneous
- 効能・効果: chronic lymphocytic leukemia
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- ATCコード
- L01XX52
- 一般的な剤形
- 錠剤
- 一般的な規格
- 10 mg
- 既知の相互作用
- 68 (併用禁忌: 5 · 重大: 37 · 中等度: 23 · 軽度: 3)
- 商品名
- 3
- 国・市場
- 3
何に使われるか
作用のしくみ
Selective, orally bioavailable small-molecule inhibitor of BCL-2, an anti-apoptotic protein. It binds BCL-2 directly, displacing pro-apoptotic proteins like BIM, which restores apoptosis through mitochondrial outer membrane permeabilization and caspase activation.
成人の通常用量（添付文書の要約）
CLL/SLL: 5-week ramp-up orally once daily (Week 1 20 mg, Week 2 50 mg, Week 3 100 mg, Week 4 200 mg), then 400 mg once daily from Week 5 and beyond
妊娠と授乳
- 妊娠
- Unsafe May cause fetal harm: in mice it caused embryo loss and lower fetal weight at about 1.2 times human exposure; no malformations; no human data. Avoid; use effective contraception during treatment and for 30 days after the last dose.
- 授乳
- Unsafe No human milk data; it passes into rat milk. Because of possible serious infant reactions, do not breastfeed during treatment and for 1 week after the last dose. LactMed: most sources advise against breastfeeding during cancer drug therapy.
報告されている副作用
- Neutropenia
- Thrombocytopenia
- Anemia
- Diarrhea
- Nausea
- Fatigue
禁忌
- Concomitant use with strong CYP3A inhibitors at initiation and during the ramp-up phase in patients with CLL/SLL, due to increased TLS risk
注意が必要な方
- Tumor lysis syndrome, including fatal events and renal failure requiring dialysis; assess risk, give hydration and anti-hyperuricemics, and monitor blood chemistries
- Neutropenia: monitor complete blood counts throughout treatment and consider supportive measures
- Fatal and serious infections such as pneumonia and sepsis; withhold for Grade 3 and 4 infection until resolution
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (68)
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
- Apalutamide + Venetoclax Major
- Aprepitant + Venetoclax Major
- Armodafinil + Venetoclax Major
- Bosentan + Venetoclax Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Venetoclaxの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を7日間無料でお試し。カード登録不要。
よくある質問
What is Venetoclax used for?
Venetoclax is a medicine in the class miscellaneous. It is used for Chronic lymphocytic leukemia, Leukemia.
What side effects have been reported with Venetoclax?
Neutropenia, Thrombocytopenia, Anemia, Diarrhea, Nausea, Fatigue.
Can Venetoclax be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm: in mice it caused embryo loss and lower fetal weight at about 1.2 times human exposure; no malformations; no human data. Avoid; use effective contraception during treatment and for 30 days after the last dose. Breastfeeding: Unsafe. No human milk data; it passes into rat milk. Because of possible serious infant reactions, do not breastfeed during treatment and for 1 week after the last dose. LactMed: most sources advise against breastfeeding during cancer drug therapy.
What does Venetoclax interact with?
MediHelp lists 68 known interactions for Venetoclax. Contraindicated: 5 · Major: 37 · Moderate: 23 · Minor: 3. The most serious include Clarithromycin, Itraconazole, Ketoconazole.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
