相互作用
Venetoclax + Voriconazole
重症度: 併用禁忌
Venetoclax and Voriconazole: contraindicated interaction.
最終更新日 出典: US FDA label
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概要
Voriconazole increases venetoclax exposure, raising the risk of tumor lysis syndrome and neutropenia, especially during dose ramp-up. After ramp-up the combination may be used only with a substantial venetoclax dose reduction.
この相互作用をわかりやすく説明すると
Venetoclax and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Venetoclax belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
なぜ起こるのか
Strong CYP3A4 inhibition (and possible P-gp inhibition) reduces venetoclax clearance.
対処法
Avoid during initiation and ramp-up in CLL/SLL. After ramp-up, reduce venetoclax dose per labeling and monitor blood counts and for toxicity.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、VenetoclaxとVoriconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Voriconazoleのその他の相互作用
Venetoclaxのその他の相互作用
よくある質問
Can I take Venetoclax with Voriconazole?
MediHelp rates the interaction as contraindicated. Venetoclax and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole increases venetoclax exposure, raising the risk of tumor lysis syndrome and neutropenia, especially during dose ramp-up. After ramp-up the combination may be used only with a substantial venetoclax dose reduction.
How serious is the interaction between Venetoclax and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during initiation and ramp-up in CLL/SLL. After ramp-up, reduce venetoclax dose per labeling and monitor blood counts and for toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
