医薬品リファレンス
Vorinostat
Vorinostat is a medicine in the class oncology. It is used for lymphoma.
- 薬効分類: Oncology
- 効能・効果: lymphoma
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- 一般的な剤形
- カプセル剤
- 一般的な規格
- 100 mg
- 既知の相互作用
- 109 (併用禁忌: 1 · 重大: 32 · 中等度: 74 · 軽度: 2)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Inhibits histone deacetylases HDAC1, HDAC2, HDAC3 (Class I) and HDAC6 (Class II), causing accumulation of acetylated histones, open chromatin and transcriptional activation, and in vitro cell cycle arrest and/or apoptosis of some transformed cells.
成人の通常用量（添付文書の要約）
Cutaneous T-cell lymphoma (cutaneous manifestations, after two systemic therapies): 400 mg orally once daily with food; continue as long as no progressive disease or unacceptable toxicity
妊娠と授乳
- 妊娠
- Unsafe Can cause fetal harm: an HDAC inhibitor that crosses the placenta; in rats and rabbits it harmed development at about half the human exposure. Avoid; pregnancy test within 7 days before starting; contraception during and for 6 months after (men with female partners: 3 months).
- 授乳
- Unsafe No data on passage into milk or infant effects. No LactMed record. Because of possible serious reactions in the infant, do not breastfeed during treatment and for at least 1 week after the last dose.
報告されている副作用
- Diarrhea
- Fatigue
- Nausea
- Dysgeusia
- Thrombocytopenia
- Anorexia
注意が必要な方
- Thromboembolism: pulmonary embolism occurred in 5% (4/86) and DVT reported; monitor for signs and symptoms.
- Myelosuppression: dose-related thrombocytopenia and anemia; monitor blood counts every 2 weeks for the first 2 months, then monthly.
- Gastrointestinal toxicity: nausea, vomiting, diarrhea may need antiemetics, antidiarrheals and fluid/electrolyte replacement; control pre-existing symptoms before starting.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (109)
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
- Clarithromycin + Vorinostat Major
- Clozapine + Vorinostat Major
- Deferiprone + Vorinostat Major
- Dronedarone + Vorinostat Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Vorinostatの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を7日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Vorinostat used for?
Vorinostat is a medicine in the class oncology. It is used for Lymphoma.
What side effects have been reported with Vorinostat?
Diarrhea, Fatigue, Nausea, Dysgeusia, Thrombocytopenia, Anorexia.
Can Vorinostat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: an HDAC inhibitor that crosses the placenta; in rats and rabbits it harmed development at about half the human exposure. Avoid; pregnancy test within 7 days before starting; contraception during and for 6 months after (men with female partners: 3 months). Breastfeeding: Unsafe. No data on passage into milk or infant effects. No LactMed record. Because of possible serious reactions in the infant, do not breastfeed during treatment and for at least 1 week after the last dose.
What does Vorinostat interact with?
MediHelp lists 109 known interactions for Vorinostat. Contraindicated: 1 · Major: 32 · Moderate: 74 · Minor: 2. The most serious include Thioridazine, Amiodarone, Amisulpride.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
