相互作用
Amisulpride + Vorinostat
重症度: 重大
Amisulpride and Vorinostat: major interaction.
最終更新日
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概要
Both drugs can prolong the QT interval, so giving them together may add to the risk of serious ventricular arrhythmias, including torsades de pointes. The risk rises further with electrolyte disturbance, bradycardia or underlying cardiac disease.
この相互作用をわかりやすく説明すると
Amisulpride and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Vorinostat belongs to Oncology.
なぜ起こるのか
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
対処法
Avoid the combination where an alternative exists. If it cannot be avoided, obtain a baseline ECG, monitor ECGs during treatment and correct potassium and magnesium abnormalities.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとVorinostatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amisulprideのその他の相互作用
Vorinostatのその他の相互作用
よくある質問
Can I take Amisulpride with Vorinostat?
MediHelp rates the interaction as major. Amisulpride and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so giving them together may add to the risk of serious ventricular arrhythmias, including torsades de pointes. The risk rises further with electrolyte disturbance, bradycardia or underlying cardiac disease.
How serious is the interaction between Amisulpride and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If it cannot be avoided, obtain a baseline ECG, monitor ECGs during treatment and correct potassium and magnesium abnormalities.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
