医薬品リファレンス
Zidovudine
Zidovudine is a medicine in the class anti virals. It is used for hiv.
- 薬効分類: Anti Virals
- 効能・効果: hiv
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Anti Virals
- 一般的な剤形
- カプセル剤, 錠剤, 溶液, 注射剤
- 一般的な規格
- 50 mg, 50 mg/5 ml, 100 mg
- 既知の相互作用
- 84 (併用禁忌: 2 · 重大: 18 · 中等度: 39 · 軽度: 25)
- 商品名
- 5
- 国・市場
- 4
何に使われるか
作用のしくみ
Inhibits thymidine kinase, Nucleoside Reverse Transcriptase Inhibitor (NRTI), Use with 3TC inhibits resistance
成人の通常用量（添付文書の要約）
HIV Infection Treatment: 300 mg PO q12hr OR 200 mg PO q8hr (600 mg/day)
妊娠と授乳
- 妊娠
- Safe Large registry data show no rise in birth defects. Long used to prevent mother-to-child HIV transmission, including IV during labour in some women. Transient raised lactate has been reported in exposed infants, without proven harm. Continue as prescribed in an HIV regimen.
- 授乳
- Safe LactMed: well studied; low milk levels, most breastfed infants have undetectable blood levels, but some developed anaemia. US label: do not breastfeed (HIV). US/WHO guidance: with a sustained undetectable viral load, breastfeeding can be supported after counselling; otherwise formula or donor milk.
報告されている副作用
- Diarrhea
- Anorexia
- Anemia
- Fever
- Granulocytopenia
注意が必要な方
- Risk of severe anemia and bone marrow depression; use with caution in patients with bone marrow compromise; hemoglobin reduction may occur 2-4 weeks
- Myopathy and myositis with pathological changes, similar to that produced by HIV-1 disease,associated with prolonged use of therapy
- Exacerbation of anemia due to ribavirin reported when zidovudine is part of HIV regimen; coadministration of ribavirin and zidovudine is not advised
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (84)
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
- Clozapine + Zidovudine Major
- Deferiprone + Zidovudine Major
- Doxorubicin + Zidovudine Major
- Elivaldogene autotemcel + Zidovudine Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Zidovudineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
WebでPro+を7日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Zidovudine used for?
Zidovudine is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Zidovudine?
Diarrhea, Anorexia, Anemia, Fever, Granulocytopenia.
Can Zidovudine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Large registry data show no rise in birth defects. Long used to prevent mother-to-child HIV transmission, including IV during labour in some women. Transient raised lactate has been reported in exposed infants, without proven harm. Continue as prescribed in an HIV regimen. Breastfeeding: Safe. LactMed: well studied; low milk levels, most breastfed infants have undetectable blood levels, but some developed anaemia. US label: do not breastfeed (HIV). US/WHO guidance: with a sustained undetectable viral load, breastfeeding can be supported after counselling; otherwise formula or donor milk.
What does Zidovudine interact with?
MediHelp lists 84 known interactions for Zidovudine. Contraindicated: 2 · Major: 18 · Moderate: 39 · Minor: 25. The most serious include Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
