相互作用
Stavudine + Zidovudine
重症度: 併用禁忌
Stavudine and Zidovudine: contraindicated interaction.
最終更新日
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概要
Zidovudine and stavudine compete for intracellular phosphorylation by thymidine kinase, reducing stavudine activation and antiviral efficacy. The combination is antagonistic and should not be used.
この相互作用をわかりやすく説明すると
Stavudine and Zidovudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Stavudine belongs to Anti Virals; Zidovudine belongs to Anti Virals.
なぜ起こるのか
Competitive inhibition of thymidine kinase phosphorylation, reducing stavudine triphosphate formation.
対処法
Do not combine. Use a regimen with only one thymidine analogue, or preferably newer NRTIs.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、StavudineとZidovudineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Zidovudineのその他の相互作用
Stavudineのその他の相互作用
よくある質問
Can I take Stavudine with Zidovudine?
MediHelp rates the interaction as contraindicated. Stavudine and Zidovudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Zidovudine and stavudine compete for intracellular phosphorylation by thymidine kinase, reducing stavudine activation and antiviral efficacy. The combination is antagonistic and should not be used.
How serious is the interaction between Stavudine and Zidovudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a regimen with only one thymidine analogue, or preferably newer NRTIs.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Zidovudine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
