医薬品リファレンス
Zolbetuximab
Zolbetuximab is a medicine in the class oncology. It is used for gastric cancer.
- 薬効分類: Oncology
- 効能・効果: gastric cancer
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- ATCコード
- L01FX31
- 一般的な剤形
- 注射剤
- 一般的な規格
- 20 mg/ml
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Claudin 18.2-directed cytolytic antibody that depletes CLDN18.2-positive cells via antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).
成人の通常用量（添付文書の要約）
HER2-negative, CLDN18.2-positive gastric/GEJ adenocarcinoma (with fluoropyrimidine- and platinum-containing chemotherapy): first dose 800 mg/m2 IV, then 600 mg/m2 IV every 3 weeks or 400 mg/m2 IV every 2 weeks; continue until disease progression or unacceptable toxicity
妊娠と授乳
- 妊娠
- Unknown No human data. No embryo-fetal toxicity in mice at about 1.9 times human exposure, though it crossed the placenta. Labels: give only if the benefit outweighs the potential risk. It is given with fluoropyrimidine and platinum chemotherapy, which can harm the fetus.
- 授乳
- Unsafe No milk data; as a large antibody little is expected in milk (LactMed). Because of possible serious reactions in the infant, US label: do not breastfeed during treatment and for 8 months after the last dose; EU label: breastfeeding not recommended during treatment.
報告されている副作用
- Nausea
- Vomiting
- Fatigue
- Decreased appetite
- Diarrhea
- Peripheral sensory neuropathy
注意が必要な方
- Hypersensitivity reactions including serious anaphylaxis and serious and fatal infusion-related reactions; monitor during and for at least 2 hours after infusion.
- Severe nausea and vomiting: VYLOY is emetogenic; premedicate with antiemetics before each infusion and manage with antiemetics or fluid replacement.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Zolbetuximabの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Zolbetuximab used for?
Zolbetuximab is a medicine in the class oncology. It is used for Gastric cancer.
What side effects have been reported with Zolbetuximab?
Nausea, Vomiting, Fatigue, Decreased appetite, Diarrhea, Peripheral sensory neuropathy.
Can Zolbetuximab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. No embryo-fetal toxicity in mice at about 1.9 times human exposure, though it crossed the placenta. Labels: give only if the benefit outweighs the potential risk. It is given with fluoropyrimidine and platinum chemotherapy, which can harm the fetus. Breastfeeding: Unsafe. No milk data; as a large antibody little is expected in milk (LactMed). Because of possible serious reactions in the infant, US label: do not breastfeed during treatment and for 8 months after the last dose; EU label: breastfeeding not recommended during treatment.
What does Zolbetuximab interact with?
MediHelp does not list a checked interaction for Zolbetuximab yet. Always tell your pharmacist about every medicine you take.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
