医薬品リファレンス

Zuranolone

Zuranolone is a medicine in the class central nervous system. It is used for depression.

薬効分類: Central Nervous System
効能・効果: depression

最終更新日 15 10月 2026 出典: US FDA label

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類: Central Nervous System
一般的な剤形: カプセル剤
既知の相互作用: 147 (重大: 52 · 中等度: 93 · 軽度: 2)
商品名: 2
国・市場: 2

剤形、規格、商品名は国によって異なります。お手元の製品をご確認ください。

何に使われるか

Depression

作用のしくみ

Neuroactive steroid GABA A receptor positive modulator; its mechanism in postpartum depression is not fully understood but is thought to be related to positive allosteric modulation of GABA A receptors.

成人の通常用量（添付文書の要約）

Postpartum depression: 50 mg orally once daily in the evening for 14 days, with fat-containing food; consider reducing to 40 mg once daily if CNS depressant effects occur; can be used alone or as adjunct to oral antidepressants

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠: Unsafe May cause fetal harm based on animal studies; human data are insufficient. Pregnancy exposure registry exists.
授乳: Unknown Present in human milk at low levels; relative infant dose <1%. No data on effects on breastfed infant. Weigh benefits of breastfeeding against maternal need.

報告されている副作用

Somnolence
Dizziness
Diarrhea
Fatigue
Nasopharyngitis
Urinary tract infection

警告（枠囲み警告）

Causes driving impairment due to CNS depressant effects. Patients should not drive or engage in other potentially hazardous activities until at least 12 hours after administration for the duration of the 14-day course. Patients may not be able to assess their own driving competence or degree of impairment.

注意が必要な方

CNS depressant effects such as somnolence and confusion; higher risk of falls; consider dose reduction or discontinuation.
Suicidal thoughts and behavior: consider changing regimen, including discontinuing, if depression worsens or suicidality emerges.
Embryo-fetal toxicity: may cause fetal harm; use effective contraception during treatment and for 1 week after the final dose.

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (147)

All 147 interactions, with severity and what to do

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アカウントを作成してPro+トライアルを始めると、Zuranoloneの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

Dosing by age, kidney and liver function, and further dose lines
Renal and hepatic dose adjustments
How to give it
Pharmacokinetics
Patient counselling points
Food interactions

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よくある質問

What is Zuranolone used for?

Zuranolone is a medicine in the class central nervous system. It is used for Depression.

What side effects have been reported with Zuranolone?

Somnolence, Dizziness, Diarrhea, Fatigue, Nasopharyngitis, Urinary tract infection. Serious warning: Causes driving impairment due to CNS depressant effects.

Can Zuranolone be taken in pregnancy or while breastfeeding?

Pregnancy: Unsafe. May cause fetal harm based on animal studies; human data are insufficient. Pregnancy exposure registry exists. Breastfeeding: Unknown. Present in human milk at low levels; relative infant dose <1%. No data on effects on breastfed infant. Weigh benefits of breastfeeding against maternal need.

What does Zuranolone interact with?

MediHelp lists 147 known interactions for Zuranolone. Major: 52 · Moderate: 93 · Minor: 2. The most serious include Alprazolam, Amobarbital, Apalutamide.

完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで

MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。

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