相互作用
Alprazolam + Zuranolone
重症度: 重大
Alprazolam and Zuranolone: major interaction.
最終更新日
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概要
Zuranolone is a neuroactive steroid GABA-A modulator that causes sedation and impaired psychomotor performance. Together with alprazolam these effects are additive, increasing the risk of somnolence, confusion and accidents.
この相互作用をわかりやすく説明すると
Alprazolam and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
なぜ起こるのか
Additive pharmacodynamic CNS depression via positive allosteric modulation of GABA-A receptors by both drugs.
対処法
Avoid the combination if possible; if unavoidable, consider reducing the zuranolone dose and counsel patients not to drive. Monitor for excessive sedation.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AlprazolamとZuranoloneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Alprazolamのその他の相互作用
Zuranoloneのその他の相互作用
よくある質問
Can I take Alprazolam with Zuranolone?
MediHelp rates the interaction as major. Alprazolam and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone is a neuroactive steroid GABA-A modulator that causes sedation and impaired psychomotor performance. Together with alprazolam these effects are additive, increasing the risk of somnolence, confusion and accidents.
How serious is the interaction between Alprazolam and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if unavoidable, consider reducing the zuranolone dose and counsel patients not to drive. Monitor for excessive sedation.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
