相互作用
Acebutolol + Clonidine
重症度: 重大
Acebutolol and Clonidine: major interaction.
最終更新日
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概要
Beta blockers can worsen rebound hypertension when clonidine is stopped or doses are missed, because unopposed alpha stimulation occurs during catecholamine surge. Both drugs also lower heart rate, so bradycardia may be additive during concurrent use.
この相互作用をわかりやすく説明すると
Acebutolol and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Beta blockade leaves alpha-mediated vasoconstriction unopposed during clonidine withdrawal, and both drugs reduce heart rate and sympathetic tone.
対処法
If clonidine must be stopped, withdraw the beta blocker first and taper clonidine gradually over several days. Monitor blood pressure and heart rate throughout.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AcebutololとClonidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clonidineのその他の相互作用
よくある質問
Can I take Acebutolol with Clonidine?
MediHelp rates the interaction as major. Acebutolol and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Beta blockers can worsen rebound hypertension when clonidine is stopped or doses are missed, because unopposed alpha stimulation occurs during catecholamine surge. Both drugs also lower heart rate, so bradycardia may be additive during concurrent use.
How serious is the interaction between Acebutolol and Clonidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If clonidine must be stopped, withdraw the beta blocker first and taper clonidine gradually over several days. Monitor blood pressure and heart rate throughout.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Amifostine, Amiodarone, Amoxapine. The full list is on the Clonidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
