相互作用
Amoxapine + Clonidine
重症度: 重大
Amoxapine and Clonidine: major interaction.
最終更新日
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概要
Tricyclic antidepressants such as amoxapine can blunt the antihypertensive effect of clonidine. Blood pressure control may be lost and hypertension may occur.
この相互作用をわかりやすく説明すると
Amoxapine and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Pharmacodynamic antagonism, with tricyclic-mediated blockade of noradrenaline reuptake and alpha-2 effects opposing clonidine.
対処法
Monitor blood pressure closely and consider another antihypertensive or antidepressant. Be aware that stopping clonidine while on a tricyclic may increase rebound hypertension risk.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmoxapineとClonidineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clonidineのその他の相互作用
よくある質問
Can I take Amoxapine with Clonidine?
MediHelp rates the interaction as major. Amoxapine and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants such as amoxapine can blunt the antihypertensive effect of clonidine. Blood pressure control may be lost and hypertension may occur.
How serious is the interaction between Amoxapine and Clonidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and consider another antihypertensive or antidepressant. Be aware that stopping clonidine while on a tricyclic may increase rebound hypertension risk.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
