相互作用
Adenovirus types 4 and 7 live + Daunorubicin
重症度: 併用禁忌
Adenovirus types 4 and 7 live and Daunorubicin: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Daunorubicin is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may fail to produce protection and could cause disseminated vaccine-strain infection. Live vaccines should not be given to patients on cytotoxic chemotherapy.
この相互作用をわかりやすく説明すると
Adenovirus types 4 and 7 live and Daunorubicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Immunosuppression from the cytotoxic agent impairs the immune response and allows the live attenuated virus to replicate uncontrolled.
対処法
Do not give the live vaccine during chemotherapy or for at least 3 months after it ends. Check immune recovery before vaccination.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Adenovirus types 4 and 7 liveとDaunorubicinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Daunorubicinのその他の相互作用
よくある質問
Can I take Adenovirus types 4 and 7 live with Daunorubicin?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Daunorubicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Daunorubicin is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may fail to produce protection and could cause disseminated vaccine-strain infection. Live vaccines should not be given to patients on cytotoxic chemotherapy.
How serious is the interaction between Adenovirus types 4 and 7 live and Daunorubicin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the live vaccine during chemotherapy or for at least 3 months after it ends. Check immune recovery before vaccination.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Belatacept, Cyclosporine, Cyclosporin. The full list is on the Daunorubicin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
