医薬品リファレンス
Daunorubicin
Daunorubicin is a medicine in the class oncology. It is used for leukemia.
- 薬効分類: Oncology
- 効能・効果: leukemia
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Oncology
- 一般的な剤形
- 注射剤
- 一般的な規格
- 20 mg
- 既知の相互作用
- 85 (併用禁忌: 1 · 重大: 12 · 中等度: 55 · 軽度: 17)
- 商品名
- 2
- 国・市場
- 1
何に使われるか
作用のしくみ
Anthracycline; intercalates between DNA base pairs, impairs topoisomerase II function and subsequently inhibits DNA and RNA replication
成人の通常用量（添付文書の要約）
Acute Nonlymphocytic Leukemia: <60 years old: 45 mg/m² IVP days 1, 2, 3 first course; days 1, 2 subsequent courses
妊娠と授乳
- 妊娠
- Unsafe Cytotoxic anthracycline: toxic to the embryo and teratogenic in animals; it can harm the fetus. Avoid, especially in the 1st trimester; if leukaemia must be treated later in pregnancy, use only with specialist care. Use effective contraception during treatment.
- 授乳
- Unsafe Not known if it passes into milk; the related doxorubicin does. Because of possible serious harm to the infant from a cytotoxic drug, do not breastfeed during treatment.
報告されている副作用
- Vomiting
- Nausea
- Alopecia
- Arrhythmias
- Discoloration of urine
- Injection site skin flare
注意が必要な方
- Contraindicated in patients with preexisting myelosuppression from other drug treatments, or patients who have received max cumulative dose of daunorubicin or doxorubicin
- Risk of severe cardiotoxicity (including CHF) & myelosuppression
- Children may be more sensitive to cardiotoxic effects than adults
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (85)
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
- Daunorubicin + Olaparib Major
- Daunorubicin + Ponatinib Major
- Daunorubicin + Siponimod Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Daunorubicinの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Dosing in older adults
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Daunorubicin used for?
Daunorubicin is a medicine in the class oncology. It is used for Leukemia.
What side effects have been reported with Daunorubicin?
Vomiting, Nausea, Alopecia, Arrhythmias, Discoloration of urine, Injection site skin flare.
Can Daunorubicin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Cytotoxic anthracycline: toxic to the embryo and teratogenic in animals; it can harm the fetus. Avoid, especially in the 1st trimester; if leukaemia must be treated later in pregnancy, use only with specialist care. Use effective contraception during treatment. Breastfeeding: Unsafe. Not known if it passes into milk; the related doxorubicin does. Because of possible serious harm to the infant from a cytotoxic drug, do not breastfeed during treatment.
What does Daunorubicin interact with?
MediHelp lists 85 known interactions for Daunorubicin. Contraindicated: 1 · Major: 12 · Moderate: 55 · Minor: 17. The most serious include Adenovirus types 4 and 7 live, Belatacept, Cyclosporin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
