相互作用
Alfentanil + Diazepam
重症度: 重大
Alfentanil and Diazepam: major interaction.
最終更新日
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概要
Combining a benzodiazepine with an opioid such as alfentanil increases the risk of profound sedation, respiratory depression, hypotension and death. Benzodiazepines are often combined with alfentanil for anesthesia, which requires dose reduction and monitoring.
この相互作用をわかりやすく説明すると
Alfentanil and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression via GABA-A and opioid receptor activity.
対処法
Reduce doses and titrate each drug carefully, with continuous monitoring of oxygenation and ventilation. Ensure airway equipment and naloxone or flumazenil are available.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AlfentanilとDiazepamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Diazepamのその他の相互作用
よくある質問
Can I take Alfentanil with Diazepam?
MediHelp rates the interaction as major. Alfentanil and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with an opioid such as alfentanil increases the risk of profound sedation, respiratory depression, hypotension and death. Benzodiazepines are often combined with alfentanil for anesthesia, which requires dose reduction and monitoring.
How serious is the interaction between Alfentanil and Diazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce doses and titrate each drug carefully, with continuous monitoring of oxygenation and ventilation. Ensure airway equipment and naloxone or flumazenil are available.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alprazolam, Amobarbital. The full list is on the Diazepam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
