相互作用
Alprazolam + Diazepam
重症度: 重大
Alprazolam and Diazepam: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Taking two benzodiazepines together gives duplicate therapy with additive sedation, psychomotor impairment, memory problems and respiratory depression. Risk of dependence and falls is also increased, especially in older adults.
この相互作用をわかりやすく説明すると
Alprazolam and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Diazepam belongs to Musculoskeletal.
なぜ起こるのか
Additive GABA-A receptor potentiation producing CNS depression.
対処法
Avoid concurrent use of two benzodiazepines; consolidate to a single agent at the lowest effective dose. If a switch is needed, taper one drug gradually.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AlprazolamとDiazepamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Diazepamのその他の相互作用
Alprazolamのその他の相互作用
よくある質問
Can I take Alprazolam with Diazepam?
MediHelp rates the interaction as major. Alprazolam and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two benzodiazepines together gives duplicate therapy with additive sedation, psychomotor impairment, memory problems and respiratory depression. Risk of dependence and falls is also increased, especially in older adults.
How serious is the interaction between Alprazolam and Diazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two benzodiazepines; consolidate to a single agent at the lowest effective dose. If a switch is needed, taper one drug gradually.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Amobarbital. The full list is on the Diazepam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
