相互作用
Alogliptin-metformin + Dalfampridine
重症度: 中等度
Alogliptin-metformin and Dalfampridine: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Both metformin and dalfampridine are eliminated through renal cation transport, so competition could raise exposure to either drug. Increased dalfampridine levels raise seizure risk, so this is of concern in patients with reduced renal function.
この相互作用をわかりやすく説明すると
Alogliptin-metformin and Dalfampridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-metformin belongs to Endocrine; Dalfampridine belongs to Central Nervous System.
なぜ起こるのか
Competition for OCT2-mediated renal tubular secretion.
対処法
Check renal function before and during combined use and monitor for metformin adverse effects and neurological symptoms; avoid dalfampridine if renal function is impaired.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Alogliptin-metforminとDalfampridineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Alogliptin-metforminのその他の相互作用
Dalfampridineのその他の相互作用
よくある質問
Can I take Alogliptin-metformin with Dalfampridine?
MediHelp rates the interaction as moderate. Alogliptin-metformin and Dalfampridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both metformin and dalfampridine are eliminated through renal cation transport, so competition could raise exposure to either drug. Increased dalfampridine levels raise seizure risk, so this is of concern in patients with reduced renal function.
How serious is the interaction between Alogliptin-metformin and Dalfampridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function before and during combined use and monitor for metformin adverse effects and neurological symptoms; avoid dalfampridine if renal function is impaired.
What other medicines interact with Alogliptin-metformin?
MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
