医薬品リファレンス
Dalfampridine
Dalfampridine is a medicine in the class central nervous system. It is used for multiple sclerosis.
- 薬効分類: Central Nervous System
- 効能・効果: multiple sclerosis
最終更新日
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要点
- 薬効分類
- Central Nervous System
- ATCコード
- N07XX07
- 一般的な剤形
- 錠剤
- 一般的な規格
- 10 mg
- 既知の相互作用
- 15 (重大: 1 · 中等度: 13 · 軽度: 1)
- 商品名
- 8
- 国・市場
- 5
何に使われるか
作用のしくみ
Mechanism not completely understood, but in animal studies shown to block potassium channels, to delay repolarization and to increase duration of action potentials in demyelinated axons Does not prolong QTc interval
成人の通常用量（添付文書の要約）
10 mg PO bid with or without food; take doses 12 hr apart
妊娠と授乳
- 妊娠
- Unknown No adequate human data. In animals, exposure during pregnancy and lactation reduced offspring survival and growth at clinically relevant doses. EU label: avoid in pregnancy as a precaution.
- 授乳
- Unknown No data on milk levels or infant effects. US label: weigh benefits; EU label: not recommended. LactMed: an alternate drug may be preferred, especially for a newborn or preterm infant.
報告されている副作用
- Headache
- Nausea
- Insomnia
- Dizziness
- Asthenia
- Back pain
注意が必要な方
- Seizures reported; permanently discontinue if seizure occurs; majority of seizures happened within days to weeks after starting the recommended dose
- Age-related decreases in renal function, and mild renal impairment is common after age 50 yr, plasma levels may approach those seen at dose of 15 mg twice daily
- Anaphylaxis and severe allergic reactions; signs and symptoms have included respiratory compromise, urticaria, and angioedema of the throat and or tongue
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (15)
- Dalfampridine + Trilaciclib Major
- Alogliptin-metformin + Dalfampridine Moderate
- Canagliflozin-metformin + Dalfampridine Moderate
- Dalfampridine + Dapagliflozin-metformin Moderate
- Dalfampridine + Dolutegravir Moderate
- Dalfampridine + Empagliflozin-metformin Moderate
- Dalfampridine + Glipizide-metformin Moderate
- Dalfampridine + Glyburide-metformin Moderate
- Dalfampridine + Linagliptin-metformin Moderate
- Dalfampridine + Metformin Moderate
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Dalfampridineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Dosing in older adults
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Dalfampridine used for?
Dalfampridine is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Dalfampridine?
Headache, Nausea, Insomnia, Dizziness, Asthenia, Back pain.
Can Dalfampridine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. In animals, exposure during pregnancy and lactation reduced offspring survival and growth at clinically relevant doses. EU label: avoid in pregnancy as a precaution. Breastfeeding: Unknown. No data on milk levels or infant effects. US label: weigh benefits; EU label: not recommended. LactMed: an alternate drug may be preferred, especially for a newborn or preterm infant.
What does Dalfampridine interact with?
MediHelp lists 15 known interactions for Dalfampridine. Major: 1 · Moderate: 13 · Minor: 1. The most serious include Trilaciclib, Alogliptin-metformin, Canagliflozin-metformin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
