相互作用
Alogliptin-pioglitazone + Bexarotene
重症度: 中等度
Alogliptin-pioglitazone and Bexarotene: moderate interaction.
最終更新日
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概要
Bexarotene acts on retinoid X receptors, which are the heterodimer partners of PPAR-gamma, and may enhance the insulin-sensitizing effect of pioglitazone. Hypoglycemia is possible, and bexarotene also commonly causes hyperlipidemia and hypothyroidism that can affect metabolic control.
この相互作用をわかりやすく説明すると
Alogliptin-pioglitazone and Bexarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-pioglitazone belongs to Endocrine; Bexarotene belongs to Oncology.
なぜ起こるのか
Additive activation of the PPAR-gamma/RXR pathway enhances insulin sensitization.
対処法
Monitor blood glucose when starting bexarotene and reduce antidiabetic doses if hypoglycemia occurs.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、Alogliptin-pioglitazoneとBexaroteneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Alogliptin-pioglitazoneのその他の相互作用
Bexaroteneのその他の相互作用
よくある質問
Can I take Alogliptin-pioglitazone with Bexarotene?
MediHelp rates the interaction as moderate. Alogliptin-pioglitazone and Bexarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene acts on retinoid X receptors, which are the heterodimer partners of PPAR-gamma, and may enhance the insulin-sensitizing effect of pioglitazone. Hypoglycemia is possible, and bexarotene also commonly causes hyperlipidemia and hypothyroidism that can affect metabolic control.
How serious is the interaction between Alogliptin-pioglitazone and Bexarotene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting bexarotene and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Alogliptin-pioglitazone?
MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
