相互作用
Bexarotene + Gemfibrozil
重症度: 重大
Bexarotene and Gemfibrozil: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Gemfibrozil has been associated with markedly raised bexarotene plasma concentrations in a labeling-described observation. Higher bexarotene exposure may worsen its dose-related toxicities such as hypertriglyceridemia, hypothyroidism and pancreatitis.
この相互作用をわかりやすく説明すると
Bexarotene and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bexarotene belongs to Oncology; Gemfibrozil belongs to Cardiovascular.
なぜ起こるのか
Proposed inhibition of CYP3A4-mediated and possibly other metabolic clearance of bexarotene by gemfibrozil; the mechanism is not firmly established.
対処法
Avoid concomitant use; bexarotene labeling advises against it. If unavoidable, monitor lipids, triglycerides and pancreatitis symptoms closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BexaroteneとGemfibrozilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Gemfibrozilのその他の相互作用
Bexaroteneのその他の相互作用
よくある質問
Can I take Bexarotene with Gemfibrozil?
MediHelp rates the interaction as major. Bexarotene and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil has been associated with markedly raised bexarotene plasma concentrations in a labeling-described observation. Higher bexarotene exposure may worsen its dose-related toxicities such as hypertriglyceridemia, hypothyroidism and pancreatitis.
How serious is the interaction between Bexarotene and Gemfibrozil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; bexarotene labeling advises against it. If unavoidable, monitor lipids, triglycerides and pancreatitis symptoms closely.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
