相互作用
Aluminum hydroxide + Penicillamine
重症度: 中等度
Aluminum hydroxide and Penicillamine: moderate interaction.
最終更新日
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概要
Aluminum-containing antacids reduce the absorption of penicillamine, which can lower its therapeutic effect in Wilson disease, cystinuria or rheumatoid arthritis. The effect is clinically relevant when doses are close together.
この相互作用をわかりやすく説明すると
Aluminum hydroxide and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Penicillamine belongs to Musculoskeletal.
なぜ起こるのか
Aluminum chelates or adsorbs penicillamine in the gut, reducing its oral absorption.
対処法
Separate penicillamine and the antacid by at least 2 hours. Monitor clinical response, such as urinary copper or cystine, if antacids are used regularly.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、Aluminum hydroxideとPenicillamineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Aluminum hydroxideのその他の相互作用
Penicillamineのその他の相互作用
よくある質問
Can I take Aluminum hydroxide with Penicillamine?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Penicillamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aluminum-containing antacids reduce the absorption of penicillamine, which can lower its therapeutic effect in Wilson disease, cystinuria or rheumatoid arthritis. The effect is clinically relevant when doses are close together.
How serious is the interaction between Aluminum hydroxide and Penicillamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate penicillamine and the antacid by at least 2 hours. Monitor clinical response, such as urinary copper or cystine, if antacids are used regularly.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
