相互作用
Amikacin + Atracurium
重症度: 重大
Amikacin and Atracurium: major interaction.
最終更新日
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概要
Aminoglycosides have intrinsic neuromuscular blocking activity and can potentiate nondepolarising blockers. This can prolong paralysis and delay recovery of spontaneous breathing, with a risk of respiratory depression or apnoea.
この相互作用をわかりやすく説明すると
Amikacin and Atracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Atracurium belongs to Musculoskeletal.
なぜ起こるのか
Aminoglycoside reduction of presynaptic acetylcholine release and postsynaptic sensitivity, additive to nondepolarising blockade.
対処法
Monitor neuromuscular function with train-of-four and reduce atracurium doses as needed. Ensure ventilatory support is available and recovery is complete before extubation.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmikacinとAtracuriumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Atracuriumのその他の相互作用
Amikacinのその他の相互作用
よくある質問
Can I take Amikacin with Atracurium?
MediHelp rates the interaction as major. Amikacin and Atracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides have intrinsic neuromuscular blocking activity and can potentiate nondepolarising blockers. This can prolong paralysis and delay recovery of spontaneous breathing, with a risk of respiratory depression or apnoea.
How serious is the interaction between Amikacin and Atracurium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and reduce atracurium doses as needed. Ensure ventilatory support is available and recovery is complete before extubation.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen, Capreomycin. The full list is on the Atracurium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
