相互作用
Atracurium + Bacitracin-neomycin-polymyxin
重症度: 重大
Atracurium and Bacitracin-neomycin-polymyxin: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Systemically absorbed polymyxin B and neomycin can have neuromuscular blocking activity and may potentiate non-depolarizing blockers. This could cause prolonged paralysis and respiratory depression. The risk with topical or irrigation use is low unless there is significant absorption from large wounds, body cavities or irrigation.
この相互作用をわかりやすく説明すると
Atracurium and Bacitracin-neomycin-polymyxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atracurium belongs to Musculoskeletal; Bacitracin-neomycin-polymyxin belongs to Anti Bacterial.
なぜ起こるのか
Polymyxin B and neomycin reduce presynaptic acetylcholine release and postsynaptic sensitivity, adding to non-depolarizing neuromuscular blockade.
対処法
Avoid peritoneal or wound irrigation with these antibiotics around anesthesia where possible. Monitor neuromuscular function and be prepared for ventilatory support, noting that calcium may be needed for reversal.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtracuriumとBacitracin-neomycin-polymyxinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Bacitracin-neomycin-polymyxinのその他の相互作用
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin 重大
- Bacitracin-neomycin-polymyxin + Capreomycin 重大
- Bacitracin-neomycin-polymyxin + Cidofovir 重大
- Bacitracin-neomycin-polymyxin + Cisatracurium 重大
- Bacitracin-neomycin-polymyxin + Pancuronium 重大
- Bacitracin-neomycin-polymyxin + Rocuronium 重大
Atracuriumのその他の相互作用
よくある質問
Can I take Atracurium with Bacitracin-neomycin-polymyxin?
MediHelp rates the interaction as major. Atracurium and Bacitracin-neomycin-polymyxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemically absorbed polymyxin B and neomycin can have neuromuscular blocking activity and may potentiate non-depolarizing blockers. This could cause prolonged paralysis and respiratory depression. The risk with topical or irrigation use is low unless there is significant absorption from large wounds, body cavities or irrigation.
How serious is the interaction between Atracurium and Bacitracin-neomycin-polymyxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid peritoneal or wound irrigation with these antibiotics around anesthesia where possible. Monitor neuromuscular function and be prepared for ventilatory support, noting that calcium may be needed for reversal.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Capreomycin, Cidofovir. The full list is on the Bacitracin-neomycin-polymyxin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
