相互作用
Amitriptyline + Benztropine
重症度: 中等度
Amitriptyline and Benztropine: moderate interaction.
最終更新日
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概要
Both drugs are strongly anticholinergic, so combined use can cause marked dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Elderly patients are at risk of delirium, paralytic ileus and heat intolerance.
この相互作用をわかりやすく説明すると
Amitriptyline and Benztropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Benztropine belongs to Central Nervous System.
なぜ起こるのか
Additive blockade of muscarinic acetylcholine receptors.
対処法
Monitor for anticholinergic toxicity, especially cognitive effects, urinary retention and constipation. Use the lowest effective doses and review whether benztropine is still needed.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmitriptylineとBenztropineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amitriptylineのその他の相互作用
Benztropineのその他の相互作用
よくある質問
Can I take Amitriptyline with Benztropine?
MediHelp rates the interaction as moderate. Amitriptyline and Benztropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are strongly anticholinergic, so combined use can cause marked dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia. Elderly patients are at risk of delirium, paralytic ileus and heat intolerance.
How serious is the interaction between Amitriptyline and Benztropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially cognitive effects, urinary retention and constipation. Use the lowest effective doses and review whether benztropine is still needed.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
