相互作用
Amitriptyline + Isocarboxazid
重症度: 併用禁忌
Amitriptyline and Isocarboxazid: contraindicated interaction.
最終更新日
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概要
Amitriptyline blocks reuptake of serotonin and noradrenaline while isocarboxazid stops their breakdown. Together they can precipitate serotonin syndrome or a hypertensive crisis.
この相互作用をわかりやすく説明すると
Amitriptyline and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amitriptyline belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
なぜ起こるのか
MAO inhibition combined with monoamine reuptake inhibition causes excess synaptic serotonin and noradrenaline
対処法
Contraindicated; allow at least 14 days after stopping an irreversible MAOI before starting amitriptyline (and 2 weeks the other way around).
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、AmitriptylineとIsocarboxazidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amitriptylineのその他の相互作用
Isocarboxazidのその他の相互作用
よくある質問
Can I take Amitriptyline with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Amitriptyline and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amitriptyline blocks reuptake of serotonin and noradrenaline while isocarboxazid stops their breakdown. Together they can precipitate serotonin syndrome or a hypertensive crisis.
How serious is the interaction between Amitriptyline and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; allow at least 14 days after stopping an irreversible MAOI before starting amitriptyline (and 2 weeks the other way around).
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Methylene blue, Phenelzine, Pimozide. The full list is on the Amitriptyline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
