相互作用
Amitriptyline + Ivosidenib
重症度: 重大
Amitriptyline and Ivosidenib: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Both drugs prolong the QT interval. Combined use increases the risk of torsades de pointes.
この相互作用をわかりやすく説明すると
Amitriptyline and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Ivosidenib belongs to Oncology.
なぜ起こるのか
Additive QT prolongation.
対処法
Use an alternative antidepressant where possible. If both are needed, monitor ECG and electrolytes and reduce ivosidenib as labeling advises for QT prolongation.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmitriptylineとIvosidenibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amitriptylineのその他の相互作用
Ivosidenibのその他の相互作用
よくある質問
Can I take Amitriptyline with Ivosidenib?
MediHelp rates the interaction as major. Amitriptyline and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval. Combined use increases the risk of torsades de pointes.
How serious is the interaction between Amitriptyline and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antidepressant where possible. If both are needed, monitor ECG and electrolytes and reduce ivosidenib as labeling advises for QT prolongation.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
