相互作用
Amlodipine-atorvastatin + Cobicistat
重症度: 重大
Amlodipine-atorvastatin and Cobicistat: major interaction.
最終更新日
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概要
Cobicistat is a strong CYP3A4 inhibitor and also inhibits OATP1B1/1B3 and P-gp. It can substantially increase exposure to amlodipine and atorvastatin, raising risks of hypotension, edema and statin myopathy.
この相互作用をわかりやすく説明すると
Amlodipine-atorvastatin and Cobicistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Cobicistat belongs to Miscellaneous.
なぜ起こるのか
Strong CYP3A4 and transporter inhibition by cobicistat reduces clearance of both amlodipine and atorvastatin.
対処法
Use a lower amlodipine dose with blood pressure monitoring, and limit atorvastatin to the lowest effective dose per labeling, or choose a statin with less interaction such as rosuvastatin or pravastatin at low dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amlodipine-atorvastatinとCobicistatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-atorvastatinのその他の相互作用
Cobicistatのその他の相互作用
よくある質問
Can I take Amlodipine-atorvastatin with Cobicistat?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Cobicistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a strong CYP3A4 inhibitor and also inhibits OATP1B1/1B3 and P-gp. It can substantially increase exposure to amlodipine and atorvastatin, raising risks of hypotension, edema and statin myopathy.
How serious is the interaction between Amlodipine-atorvastatin and Cobicistat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower amlodipine dose with blood pressure monitoring, and limit atorvastatin to the lowest effective dose per labeling, or choose a statin with less interaction such as rosuvastatin or pravastatin at low dose.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
