相互作用
Amlodipine-atorvastatin + Clarithromycin
重症度: 重大
Amlodipine-atorvastatin and Clarithromycin: major interaction.
最終更新日
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概要
Clarithromycin strongly inhibits CYP3A4, raising amlodipine and atorvastatin concentrations. This increases the risk of hypotension, edema and acute kidney injury, and of statin-related myopathy or rhabdomyolysis.
この相互作用をわかりやすく説明すると
Amlodipine-atorvastatin and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Clarithromycin belongs to Anti Bacterial.
なぜ起こるのか
Clarithromycin inhibits CYP3A4 (and P-glycoprotein), reducing metabolism of amlodipine and atorvastatin.
対処法
Avoid the combination if possible by using a non-interacting antibiotic such as azithromycin, or suspend atorvastatin during the course. If used, limit the atorvastatin dose and monitor blood pressure and muscle symptoms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Amlodipine-atorvastatinとClarithromycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-atorvastatinのその他の相互作用
Clarithromycinのその他の相互作用
よくある質問
Can I take Amlodipine-atorvastatin with Clarithromycin?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin strongly inhibits CYP3A4, raising amlodipine and atorvastatin concentrations. This increases the risk of hypotension, edema and acute kidney injury, and of statin-related myopathy or rhabdomyolysis.
How serious is the interaction between Amlodipine-atorvastatin and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible by using a non-interacting antibiotic such as azithromycin, or suspend atorvastatin during the course. If used, limit the atorvastatin dose and monitor blood pressure and muscle symptoms.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
