相互作用
Amlodipine-benazepril + Carbidopa
重症度: 中等度
Amlodipine-benazepril and Carbidopa: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Carbidopa, usually given with levodopa, increases dopamine formation outside the brain and can enhance the blood pressure lowering of antihypertensives. Orthostatic hypotension and dizziness may become more pronounced, especially when levodopa therapy is started or increased.
この相互作用をわかりやすく説明すると
Amlodipine-benazepril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Carbidopa belongs to Central Nervous System.
なぜ起こるのか
Additive pharmacodynamic hypotensive effect from peripheral dopaminergic activity of levodopa combined with vasodilation and ACE inhibition.
対処法
Monitor supine and standing blood pressure when carbidopa-levodopa is started or titrated. Reduce the antihypertensive dose if symptomatic hypotension occurs.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amlodipine-benazeprilとCarbidopaの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Amlodipine-benazeprilのその他の相互作用
Carbidopaのその他の相互作用
よくある質問
Can I take Amlodipine-benazepril with Carbidopa?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa, usually given with levodopa, increases dopamine formation outside the brain and can enhance the blood pressure lowering of antihypertensives. Orthostatic hypotension and dizziness may become more pronounced, especially when levodopa therapy is started or increased.
How serious is the interaction between Amlodipine-benazepril and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when carbidopa-levodopa is started or titrated. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
