Drug interactions
Amlodipine-benazepril + Carbidopa
Severity: Moderate
Amlodipine-benazepril and Carbidopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa, usually given with levodopa, increases dopamine formation outside the brain and can enhance the blood pressure lowering of antihypertensives. Orthostatic hypotension and dizziness may become more pronounced, especially when levodopa therapy is started or increased.
What this interaction means in plain words
Amlodipine-benazepril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Carbidopa belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effect from peripheral dopaminergic activity of levodopa combined with vasodilation and ACE inhibition.
What to do
Monitor supine and standing blood pressure when carbidopa-levodopa is started or titrated. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Amlodipine-benazepril with Carbidopa?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Carbidopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa, usually given with levodopa, increases dopamine formation outside the brain and can enhance the blood pressure lowering of antihypertensives. Orthostatic hypotension and dizziness may become more pronounced, especially when levodopa therapy is started or increased.
How serious is the interaction between Amlodipine-benazepril and Carbidopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when carbidopa-levodopa is started or titrated. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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