相互作用
Amlodipine-hydrochlorothiazide-valsartan + Fosinopril
重症度: 重大
Amlodipine-hydrochlorothiazide-valsartan and Fosinopril: major interaction.
最終更新日
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概要
Fosinopril combined with valsartan causes dual renin-angiotensin system blockade, increasing the risk of hypotension, hyperkalemia and acute kidney injury. The combination offers little additional benefit.
この相互作用をわかりやすく説明すると
Amlodipine-hydrochlorothiazide-valsartan and Fosinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Fosinopril belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic blockade of the renin-angiotensin-aldosterone system at the ACE and angiotensin receptor levels.
対処法
Avoid concurrent use; keep to a single renin-angiotensin blocker. If unavoidable, monitor potassium, renal function and blood pressure closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amlodipine-hydrochlorothiazide-valsartanとFosinoprilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-hydrochlorothiazide-valsartanのその他の相互作用
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan 併用禁忌
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide 併用禁忌
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan 併用禁忌
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan 重大
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan 重大
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan 重大
Fosinoprilのその他の相互作用
よくある質問
Can I take Amlodipine-hydrochlorothiazide-valsartan with Fosinopril?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Fosinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosinopril combined with valsartan causes dual renin-angiotensin system blockade, increasing the risk of hypotension, hyperkalemia and acute kidney injury. The combination offers little additional benefit.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Fosinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; keep to a single renin-angiotensin blocker. If unavoidable, monitor potassium, renal function and blood pressure closely.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
