相互作用
Amlodipine-hydrochlorothiazide-valsartan + Sparsentan
重症度: 併用禁忌
Amlodipine-hydrochlorothiazide-valsartan and Sparsentan: contraindicated interaction.
最終更新日
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概要
Sparsentan blocks the angiotensin II receptor in addition to endothelin receptors, so adding valsartan duplicates the effect. This raises the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
この相互作用をわかりやすく説明すると
Amlodipine-hydrochlorothiazide-valsartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
なぜ起こるのか
Additive pharmacodynamic angiotensin II type 1 receptor blockade.
対処法
Do not combine; stop the ARB-containing product before starting sparsentan and use another agent for blood pressure control if needed.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Amlodipine-hydrochlorothiazide-valsartanとSparsentanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-hydrochlorothiazide-valsartanのその他の相互作用
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan 併用禁忌
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide 併用禁忌
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan 重大
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan 重大
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan 重大
- Amiloride + Amlodipine-hydrochlorothiazide-valsartan 重大
Sparsentanのその他の相互作用
よくある質問
Can I take Amlodipine-hydrochlorothiazide-valsartan with Sparsentan?
MediHelp rates the interaction as contraindicated. Amlodipine-hydrochlorothiazide-valsartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan blocks the angiotensin II receptor in addition to endothelin receptors, so adding valsartan duplicates the effect. This raises the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop the ARB-containing product before starting sparsentan and use another agent for blood pressure control if needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Aceclofenac. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
