相互作用
Amlodipine-olmesartan + Cyclosporine
重症度: 重大
Amlodipine-olmesartan and Cyclosporine: major interaction.
最終更新日
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概要
Cyclosporine may increase amlodipine exposure, and amlodipine can raise cyclosporine trough levels in some patients. Olmesartan with cyclosporine adds a risk of hyperkalemia and reduced renal function. Cyclosporine toxicity includes nephrotoxicity and hypertension.
この相互作用をわかりやすく説明すると
Amlodipine-olmesartan and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
CYP3A4 and P-glycoprotein interactions alter levels of both drugs, and cyclosporine renal vasoconstriction together with ARB efferent dilation increases hyperkalemia and renal risk.
対処法
Monitor cyclosporine trough levels, serum creatinine and potassium, and adjust cyclosporine dose as needed. Reduce amlodipine dose if hypotension or edema occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amlodipine-olmesartanとCyclosporineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-olmesartanのその他の相互作用
よくある質問
Can I take Amlodipine-olmesartan with Cyclosporine?
MediHelp rates the interaction as major. Amlodipine-olmesartan and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine may increase amlodipine exposure, and amlodipine can raise cyclosporine trough levels in some patients. Olmesartan with cyclosporine adds a risk of hyperkalemia and reduced renal function. Cyclosporine toxicity includes nephrotoxicity and hypertension.
How serious is the interaction between Amlodipine-olmesartan and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels, serum creatinine and potassium, and adjust cyclosporine dose as needed. Reduce amlodipine dose if hypotension or edema occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
