相互作用
Amlodipine-olmesartan + Benazepril
重症度: 重大
Amlodipine-olmesartan and Benazepril: major interaction.
最終更新日
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概要
Combining an angiotensin receptor blocker with an ACE inhibitor produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a proven cardiovascular benefit in most patients.
この相互作用をわかりやすく説明すると
Amlodipine-olmesartan and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan belongs to Cardiovascular; Benazepril belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two sites, reducing glomerular filtration pressure and aldosterone-mediated potassium excretion.
対処法
Avoid the combination and use a single RAS blocker with amlodipine. If it is unavoidable, monitor blood pressure, serum potassium and creatinine closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Amlodipine-olmesartanとBenazeprilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-olmesartanのその他の相互作用
Benazeprilのその他の相互作用
よくある質問
Can I take Amlodipine-olmesartan with Benazepril?
MediHelp rates the interaction as major. Amlodipine-olmesartan and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an angiotensin receptor blocker with an ACE inhibitor produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a proven cardiovascular benefit in most patients.
How serious is the interaction between Amlodipine-olmesartan and Benazepril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a single RAS blocker with amlodipine. If it is unavoidable, monitor blood pressure, serum potassium and creatinine closely.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
