相互作用
Amlodipine-olmesartan-hydrochlorothiazide + Benazepril
重症度: 重大
Amlodipine-olmesartan-hydrochlorothiazide and Benazepril: major interaction.
最終更新日
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概要
Combining an angiotensin receptor blocker with an ACE inhibitor produces dual blockade of the renin-angiotensin system. This raises the risk of hypotension, hyperkalemia and acute kidney injury, and outcome trials showed no cardiovascular benefit over a single agent in most patients.
この相互作用をわかりやすく説明すると
Amlodipine-olmesartan-hydrochlorothiazide and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Benazepril belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two sites, which reduces glomerular filtration pressure and aldosterone-mediated potassium excretion.
対処法
Avoid the combination and use only one RAS blocker. If it is unavoidable, monitor serum potassium, creatinine and blood pressure closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-olmesartan-hydrochlorothiazideのその他の相互作用
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide 併用禁忌
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide 併用禁忌
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan 併用禁忌
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide 重大
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide 重大
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide 重大
Benazeprilのその他の相互作用
よくある質問
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Benazepril?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an angiotensin receptor blocker with an ACE inhibitor produces dual blockade of the renin-angiotensin system. This raises the risk of hypotension, hyperkalemia and acute kidney injury, and outcome trials showed no cardiovascular benefit over a single agent in most patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Benazepril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use only one RAS blocker. If it is unavoidable, monitor serum potassium, creatinine and blood pressure closely.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
