相互作用
Benazepril + Sacubitril-valsartan
重症度: 併用禁忌
Benazepril and Sacubitril-valsartan: contraindicated interaction.
最終更新日
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概要
Sacubitril inhibits neprilysin and so increases bradykinin, as does the ACE inhibitor benazepril. Combined, the rise in bradykinin substantially increases the risk of angioedema, which can involve the airway.
この相互作用をわかりやすく説明すると
Benazepril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Benazepril belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
なぜ起こるのか
Neprilysin plus ACE inhibition causes additive bradykinin accumulation
対処法
Contraindicated: stop the ACE inhibitor at least 36 hours before starting sacubitril/valsartan and do not restart one within 36 hours of the other.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BenazeprilとSacubitril-valsartanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sacubitril-valsartanのその他の相互作用
Benazeprilのその他の相互作用
よくある質問
Can I take Benazepril with Sacubitril-valsartan?
MediHelp rates the interaction as contraindicated. Benazepril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sacubitril inhibits neprilysin and so increases bradykinin, as does the ACE inhibitor benazepril. Combined, the rise in bradykinin substantially increases the risk of angioedema, which can involve the airway.
How serious is the interaction between Benazepril and Sacubitril-valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated: stop the ACE inhibitor at least 36 hours before starting sacubitril/valsartan and do not restart one within 36 hours of the other.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Captopril, Enalapril. The full list is on the Sacubitril-valsartan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
