相互作用
Amlodipine-olmesartan-hydrochlorothiazide + Canagliflozin
重症度: 中等度
Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin: moderate interaction.
最終更新日
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概要
Canagliflozin causes osmotic diuresis and can add to the volume depletion and blood pressure lowering of an ARB and thiazide, with a risk of hypotension and acute kidney injury. Canagliflozin may also modestly increase potassium in some patients, especially with an ARB and renal impairment.
この相互作用をわかりやすく説明すると
Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Canagliflozin belongs to Endocrine.
なぜ起こるのか
Additive diuretic and hypotensive effects, with possible additive effects on potassium and renal hemodynamics.
対処法
Assess volume status before starting canagliflozin and consider reducing the diuretic dose. Monitor blood pressure, renal function and potassium.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、Amlodipine-olmesartan-hydrochlorothiazideとCanagliflozinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amlodipine-olmesartan-hydrochlorothiazideのその他の相互作用
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide 併用禁忌
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide 併用禁忌
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan 併用禁忌
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide 重大
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide 重大
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide 重大
Canagliflozinのその他の相互作用
よくある質問
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Canagliflozin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin causes osmotic diuresis and can add to the volume depletion and blood pressure lowering of an ARB and thiazide, with a risk of hypotension and acute kidney injury. Canagliflozin may also modestly increase potassium in some patients, especially with an ARB and renal impairment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting canagliflozin and consider reducing the diuretic dose. Monitor blood pressure, renal function and potassium.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
