Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Canagliflozin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin causes osmotic diuresis and can add to the volume depletion and blood pressure lowering of an ARB and thiazide, with a risk of hypotension and acute kidney injury. Canagliflozin may also modestly increase potassium in some patients, especially with an ARB and renal impairment.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Canagliflozin belongs to Endocrine.
Why it happens
Additive diuretic and hypotensive effects, with possible additive effects on potassium and renal hemodynamics.
What to do
Assess volume status before starting canagliflozin and consider reducing the diuretic dose. Monitor blood pressure, renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Canagliflozin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin causes osmotic diuresis and can add to the volume depletion and blood pressure lowering of an ARB and thiazide, with a risk of hypotension and acute kidney injury. Canagliflozin may also modestly increase potassium in some patients, especially with an ARB and renal impairment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting canagliflozin and consider reducing the diuretic dose. Monitor blood pressure, renal function and potassium.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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