相互作用
Amoxapine + Tranylcypromine
重症度: 併用禁忌
Amoxapine and Tranylcypromine: contraindicated interaction.
最終更新日
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概要
Amoxapine blocks reuptake of norepinephrine and serotonin, and tranylcypromine is an irreversible nonselective MAOI. Together they can cause serotonin syndrome or hypertensive crisis.
この相互作用をわかりやすく説明すると
Amoxapine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Reuptake inhibition combined with irreversible MAO inhibition increases synaptic serotonin and norepinephrine.
対処法
Do not combine. Observe a washout of at least 14 days after stopping tranylcypromine before starting amoxapine, and an adequate washout of amoxapine before starting an MAOI.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmoxapineとTranylcypromineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tranylcypromineのその他の相互作用
よくある質問
Can I take Amoxapine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Amoxapine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amoxapine blocks reuptake of norepinephrine and serotonin, and tranylcypromine is an irreversible nonselective MAOI. Together they can cause serotonin syndrome or hypertensive crisis.
How serious is the interaction between Amoxapine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Observe a washout of at least 14 days after stopping tranylcypromine before starting amoxapine, and an adequate washout of amoxapine before starting an MAOI.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Atomoxetine. The full list is on the Tranylcypromine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
