相互作用
Amoxicillin-clavulanic acid + Methotrexate
重症度: 重大
Amoxicillin-clavulanic acid and Methotrexate: major interaction.
最終更新日
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概要
Penicillins can raise methotrexate concentrations and prolong exposure, leading to increased myelosuppression, mucositis and other toxicity. The effect is most concerning with high-dose methotrexate or impaired renal function.
この相互作用をわかりやすく説明すると
Amoxicillin-clavulanic acid and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Methotrexate belongs to Oncology.
なぜ起こるのか
Competition for renal tubular secretion reduces methotrexate renal clearance.
対処法
Monitor methotrexate levels, renal function and blood counts when co-administered, and consider an alternative antibiotic during high-dose methotrexate.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amoxicillin-clavulanic acidとMethotrexateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amoxicillin-clavulanic acidのその他の相互作用
Methotrexateのその他の相互作用
よくある質問
Can I take Amoxicillin-clavulanic acid with Methotrexate?
MediHelp rates the interaction as major. Amoxicillin-clavulanic acid and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penicillins can raise methotrexate concentrations and prolong exposure, leading to increased myelosuppression, mucositis and other toxicity. The effect is most concerning with high-dose methotrexate or impaired renal function.
How serious is the interaction between Amoxicillin-clavulanic acid and Methotrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor methotrexate levels, renal function and blood counts when co-administered, and consider an alternative antibiotic during high-dose methotrexate.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Pexidartinib, Pretomanid, Allopurinol. The full list is on the Amoxicillin-clavulanic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
