相互作用
Amoxicillin-clavulanic acid + Pretomanid
重症度: 重大
Amoxicillin-clavulanic acid and Pretomanid: major interaction.
最終更新日
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概要
The pretomanid-containing regimen is associated with hepatotoxicity, and labeling advises avoiding other hepatotoxic agents. Amoxicillin-clavulanate can cause cholestatic or mixed liver injury. Concurrent use could raise the risk of serious hepatic injury.
この相互作用をわかりやすく説明すると
Amoxicillin-clavulanic acid and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Pretomanid belongs to Anti Bacterial.
なぜ起こるのか
Additive hepatotoxicity from pretomanid-based therapy and clavulanate-associated liver injury.
対処法
Avoid amoxicillin-clavulanate during pretomanid therapy and select a less hepatotoxic antibiotic. If it cannot be avoided, monitor liver function tests frequently.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amoxicillin-clavulanic acidとPretomanidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amoxicillin-clavulanic acidのその他の相互作用
Pretomanidのその他の相互作用
よくある質問
Can I take Amoxicillin-clavulanic acid with Pretomanid?
MediHelp rates the interaction as major. Amoxicillin-clavulanic acid and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The pretomanid-containing regimen is associated with hepatotoxicity, and labeling advises avoiding other hepatotoxic agents. Amoxicillin-clavulanate can cause cholestatic or mixed liver injury. Concurrent use could raise the risk of serious hepatic injury.
How serious is the interaction between Amoxicillin-clavulanic acid and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid amoxicillin-clavulanate during pretomanid therapy and select a less hepatotoxic antibiotic. If it cannot be avoided, monitor liver function tests frequently.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Allopurinol. The full list is on the Amoxicillin-clavulanic acid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
