相互作用
Amyl nitrite + Sildenafil
重症度: 併用禁忌
Amyl nitrite and Sildenafil: contraindicated interaction.
最終更新日
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概要
Nitrates increase cGMP via nitric oxide and sildenafil blocks its breakdown, causing profound vasodilation. This can lead to severe, potentially fatal hypotension.
この相互作用をわかりやすく説明すると
Amyl nitrite and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Additive cGMP-mediated vasodilation from nitric oxide donation and PDE5 inhibition.
対処法
Do not use together. Nitrates should be avoided for at least 24 hours after sildenafil.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amyl nitriteとSildenafilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Sildenafilのその他の相互作用
よくある質問
Can I take Amyl nitrite with Sildenafil?
MediHelp rates the interaction as contraindicated. Amyl nitrite and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nitrates increase cGMP via nitric oxide and sildenafil blocks its breakdown, causing profound vasodilation. This can lead to severe, potentially fatal hypotension.
How serious is the interaction between Amyl nitrite and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Nitrates should be avoided for at least 24 hours after sildenafil.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Atazanavir, Cobicistat, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Sildenafil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
