相互作用
Anagrelide + Milrinone
重症度: 重大
Anagrelide and Milrinone: major interaction.
最終更新日
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概要
Both drugs are PDE3 inhibitors, so combined use may enhance positive inotropic, chronotropic and vasodilatory effects. This increases the risk of tachycardia, arrhythmias, hypotension and fluid retention or heart failure complications.
この相互作用をわかりやすく説明すると
Anagrelide and Milrinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Milrinone belongs to Cardiovascular.
なぜ起こるのか
Additive phosphodiesterase 3 inhibition.
対処法
Avoid combined use where possible; if unavoidable, monitor ECG, blood pressure and heart rate closely and consider holding anagrelide during milrinone infusion.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AnagrelideとMilrinoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Milrinoneのその他の相互作用
Anagrelideのその他の相互作用
よくある質問
Can I take Anagrelide with Milrinone?
MediHelp rates the interaction as major. Anagrelide and Milrinone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are PDE3 inhibitors, so combined use may enhance positive inotropic, chronotropic and vasodilatory effects. This increases the risk of tachycardia, arrhythmias, hypotension and fluid retention or heart failure complications.
How serious is the interaction between Anagrelide and Milrinone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible; if unavoidable, monitor ECG, blood pressure and heart rate closely and consider holding anagrelide during milrinone infusion.
What other medicines interact with Milrinone?
MediHelp also lists interactions of Milrinone with, for example, Cilostazol, Enoximone, Inamrinone. The full list is on the Milrinone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
